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李蓬 博士

教授,中科院院士,長江特聘教授,國家杰出青年基金獲得者

1987年       北京師范大學                                                                              學士

1995年       美國加州大學圣地亞哥分校                                                        博士

1995-1996 新加坡國立大學分子與細胞生物學研究所                                   博士后

1996-1997 美國達拉斯德州大學西南醫學中心Howard Hughes醫學研究所  博士后

1997-2003 新加坡分子和細胞生物學研究所                                                 助理教授及研究室主任

2003-2006 香港科技大學生物系,                                                               助理教授&副教授(獲終身制)

2006-至今  清華大學生命科學學院                                                               長江學者特聘教授

 

● 研究興趣、領域:

集中于糖脂代謝的研究,包括脂滴生物學,肥胖、糖尿病和脂肪肝等代謝性疾病發生發展的分子機制。我們發現調控脂滴融合、脂滴-內質網互作的若干重要蛋白質,并且闡明了它們在肥胖、糖尿病和脂肪肝等代謝性疾病發生發展中的作用。

● 開設的課程:

《重大疾病的分子機制》

● 代表性論文:

1. Du X, Zhou L, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, and Yang H* (2020) ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. J Cell Biol. 219: pii: e201905162.
2. Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X*, Li P* (2019) Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 38:e100156.
3. Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P* (2019) The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition. Cell Rep. 28:3406-22
4. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P* (2018) Rab18 promotes lipid droplet growth by tethering the ER to lipid droplets through SNARE and NRZ interactions. J Cell Biol. 217:975-95.
5. Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P*, Xu L* (2018) Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes. Diabetes 67:1935-48.
6. Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P* (2017) HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest. 127: 1353-69.
7. Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P* (2015) Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice. Nat Commum. 6, 5949.
8. Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P* (2014) Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth. Dev Cell 30: 378-93.
9. Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M and Li P* (2013) Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes. Nat Commum. 4: 1594
10. Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P* (2012) Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 18: 235-43.
11. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P* (2011) Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 195: 953-63.
12. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P* (2009) Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab. 9: 177-90.
13. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P* (2008) Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 27: 1537-48.
14. Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P*(2007) Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation, Diabetes 56: 2523-32.
15.Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P* (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 35: 49-56.

● 榮譽、獎勵及參加學術團體的情況:

中美CUSBEA獎學金,1987
新加坡國家青年科學家獎,1999
海外杰出青年人才基金,2005
享受國務院政府特殊津貼,2008
Arthur Kornberg Memorial Lecture award,2008
何梁何利基金生命科學領域科學與技術進步獎,2012年
糖尿病/代謝研究與評論雜志編委,2006-2009
北京生物化學和分子生物學會副理事長,2006 - 至今
亞太國際分子生物學網絡組織編輯顧問委員會成員,2008-
脂類生命科學國際會議指導委員會委員,2008 - 至今


● 聯系方式:

通信地址:北京市海淀區清華大學生命科學學院(100084)
電話:010-62797133
Email:li-peng@mail.tsinghua.edu.cn
Fax:86-10-62797121 

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